Shivam Talks

Skeletal Muscle Relaxants So we have 2 types of muscle relaxants:- Those which work on the CNS ( Central ) those who work on the muscle and their NM receptors (peripheral) Central Muscle Relaxant So to use center in material relaxants we need a drug which stimulates the receptors present in the CNS and such receptors are          GABA a receptors – Diazepam      GABA b   receptors --- Baclofen      alpha 2 receptors(acts like break )- t izanidine      Another group of centrally acting muscle relaxants are those which act by inhibiting the polysynaptic reflexes examples - Mephensin ,Chlorzoxazone, thiocolchicoside   Peripheral muscle relaxants there are two types:-   directly acting and indirectly acting Directly acting :-   they directly act on the muscles d irectly acting-dantrolene :- works by blocking ryanodine receptor in endoplasmic reticulum from muscles Ryanodine receptor - it is the same receptor which helps in the release of calcium ions from the endoplasmic ret

  See, the thing I am gonna rant about Right now is that we are expected to be good at studies. Like really good, and the fact is that as we all know most people don't like studying and that's a fact.  Yeah, some people like to study, but they are not a lot as compared to the majority of us. those people who like doing other things. But the problem is, that we need to study, and it is a necessity if we want to succeed.  To those who say that many people are successful or did succeed at what they did without studies or education, then my friend you are in the wrong cause, those people did not succeed without studies or education, they did get an education, just not the regular way not the ideal way, but they did gain in-depth knowledge of their respective fields, and then they succeeded, so you have to study in some way to succeed at what it is they are doing, and it's up to you to figure out the way you want to, cause everyone has their own way, has something they like and

all the local anesthetics are Basic Drugs  local anesthetics cross the membrane in non ionized  for and block the Na channels in ionized  form  local anesthetics are of 2 types  Ester and Amide but the name of both type of local anesthetics end with  CAINE [ad]   mechanism of action of local anesthesia   Ester                                      Amide  cocaine                                     lignocaine procaine                                         bupivacaine chlorprocaine                            prilocaine  tetracaine                                 Etidocaine     benzocaine                                ropivacaine                                                  Dibucaine So What is the significance of amide and ester and why should we always keep in mind which is ester and which is amide?? ans-   we should always remember which group is ester an

 Poisoning of some Drugs poisoning caused by some drugs and how to deal with them 1. Poisoning with muscarine: Symptoms:   miosis,  blurred vision,  increased salivation,  excessive sweating,  lacrimation,  bronchial secretions,  bronchoconstriction,  bradycardia,  abdominal cramping,  increased gastric acid secretion,  diarrhea and polyuria (it might cause also tremor, convulsions and hypothermia). Miosis A s we all are well aware that muscarine is a acetylcholine agonist which in turn stimulates the cholinergic receptors which are an integral part of Parasympathetic post synaptic receptors and sympathetic sweat receptors all are triggered by acetyl choline agonist muscarine leading to all the above mentioned symptoms and so to treat it we use a Acetylcholine Antagonist which block the channels that are being stimulated leading to the blockage of all the response of the choline related reactions. Treatment:  The drug of choice is Atropine. Atropine is  not an actual antidote for org

 H ello everyone this is the Fool and today its my first day at trying this new thing ,